Surgery of AD disease
Overview about the disease:
Alzheimer's disease may be a heterogeneous condition, with the disease onset resulting from the interaction of various factors (including biological and psychosocial factors). According to current research, there are as many as 30 hypotheses and potential factors for this disease, such as family history, gender factors, head injuries, low educational levels, thyroid disease, maternal age being too high or too low, viral infections, Down syndrome, chronic illnesses, among others.
Clinical symptoms:
Classified into three stages based on the deterioration of cognitive abilities and physical functions.
Stage 1 (1-3 years): Mild dementia.
Manifestations include memory decline, prominent recent memory loss; decreased judgment ability, inability to analyze, think, or judge events, difficulty handling complex problems; being inattentive at work or in household chores, inability to independently manage shopping, financial matters, etc., social difficulties; although still capable of performing familiar daily tasks, there is confusion when encountering new things, emotional detachment, occasional irritability, and frequent suspicion; time orientation difficulties, can orient themselves in places and among people, but struggle with geographic orientation, poor visual-spatial abilities in complex structures; limited vocabulary, difficulty in naming objects.
Stage 2 (2-10 years): Moderate dementia.
Characterized by severe impairment in both recent and remote memory, a decline in simple visual-spatial abilities, time and location orientation difficulties; severe impairment in problem-solving, distinguishing similarities and differences between objects; inability to engage in outdoor activities independently, requiring assistance in dressing, personal hygiene, and maintaining appearance; inability to perform calculations; various neurological symptoms may appear, such as aphasia, apraxia, and agnosia; emotional changes from detachment to restlessness and agitation, constant wandering, and urinary incontinence may occur.
Stage 3 (8-12 years): Severe dementia.
Patients are entirely reliant on caregivers, experiencing severe memory loss with only fragments of memory remaining; unable to perform basic daily activities independently, incontinence of both urine and stool, exhibiting silence, rigid limbs, positive Babinski reflex in physical examination with primitive reflexes like strong grasping, groping, and sucking. Eventually, the patient falls into a coma and generally succumbs to complications such as infections.
Prof Qingping Xie’s illustration and vision on the brain lymphedema for AD patients:
1. Proven Efficacy: LVA, a time-tested surgical technique, has garnered global acclaim for its unparalleled effectiveness in mitigating lymphedema within the limbs. It has unequivocally demonstrated its safety and efficacy over two decades.
2. Safety Profile: Despite the pioneering nature of Professor Xie's method, it has been rigorously validated as intrinsically safe, with no recorded post-operative adversities.
3. Standardization Potential: LVA holds the potential for standardization, possibly benefiting from AI-assisted training mechanisms, thereby facilitating scalability.
4. Patient Comfort: The extracranial nature of the procedure, with an average operation duration of approximately four hours, ensures optimal patient comfort and a relatively abbreviated hospital stay.
5. Immediate Results:Patients typically experience rapid improvements in cognitive and motor functions shortly following the procedure, with sustained enhancements throughout the follow-up period due to the nature of Lymphatic reconstruction surgery.
6. Permanent assistance on Brain’s lymphatic environment: LVA surgery affords a one-time, permanent amelioration in patients' conditions by establishing a tangible pathway for protein drainage.
Purpose and role of Supermicrosurgery for AD disease:
1. Formation of new channels for lymphatic flow into veins
2.Reduce lymphatic pressure in distal tissues
3.Rebuild new lymphatic return system
Resulting:
Removal of metabolites from brain tissue
Removal of apoptotic cells from brain tissue
Maintaining normal function of brain tissue
cerebral lymphatic fluid ----- cervical lymph nodes - subclavian vein= Hyperplastic lymph nodes
The rapid development of Supermircosurgery:
High-definition microscopy technology has become an essential component of modern microsurgical procedures. This technique employs digital microscopes to enhance imaging quality, achieving extremely high magnification and high-definition images. It enables surgeons to observe tissues and organs more clearly, facilitating precise surgical procedures.
Minimally invasive surgical techniques have been widely applied in microsurgery. Compared to traditional surgery, minimally invasive procedures result in smaller incisions, reduced bleeding, and shorter recovery times, significantly lowering surgical risks.
Real-time image processing technology provides more precise imaging information during surgery, aiding surgeons in better positioning and conducting operations within the surgical area.
Currently, this technology has gained significant recognition within the medical community. Professor Luo Jianhong, a renowned scholar in neurology and former Vice President of Zhejiang University, stated: "This is indeed a creative and innovative therapy. From current studies on the brain's lymphatic system, the reflux of the brain's lymphatic system holds great potential for improving related neurological diseases. Therefore, we anticipate Director Xie Qingping's clinical research to yield encouraging results, benefiting Alzheimer's disease patients."
Professor Zhao Dewei, President of the Microsurgery Physicians Branch of the Chinese Medical Doctor Association, expressed: "The deep neck lymphatico-venous anastomosis surgery is a challenging and high-level technique in microsurgical technology. Based on the in-depth anatomical research of neck lymphatic vessels, Professor Xie Qingping's team applied supermicrosurgical anastomosis technology and fluorescence tracking technology to perform lymphatico-venous anastomosis on specific neck lymphatic vessels, achieving gratifying outcomes in the clinical practice of treating Alzheimer's disease."
brain's lymphatic drainage system, outlining its crucial role in preserving the brain's equilibrium and its impact on immune responses and surveillance. It underscores the brain lymphatic network's vital function in maintaining a balanced brain environment and its involvement in immune activities. This system plays a pivotal role in eliminating waste materials and metabolic remnants, influencing immune functions within the brain, and potentially affecting various brain-related health conditions and diseases.
Eglibility chart：
Fee structure:
The surgery for international patients:
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40K usd for the whole LVA surgery and one week of hospitalization. The LVA surgery will normally perform in total of 15-20 lymphatic-vein anastomosis on both side of the neck.
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50% deposit needed to wire transfer/direct deposit to designated hospital account, invoice and letter of hospitalization will be issued upon receipt of the payment for Visa Purposes. A scheduled surgery time can be established at that time. (Please book ahead for at least 2 weeks).
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Local vehicle Transportation for inbounding flights from Shanghai airport to Hangzhou Qiushi Hospital is included in the price. Please note we can only pick up from either Shanghai (PVG) Pudong airport or from Hangzhou Xiaoshan International Airport (HHG)